Ceramedix

Publications

  1. Dorweiler, T., Singh, A., Ganju, A., Lydic, T.A., … Kolesnick, R.N., and Busik, J.V. (2024), Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy. Cell Metab. 36 (7):1521-1533.
  2. Chenga, J., Nagesha, P. K. B., Feldman, R., Shamu, T., Zhang, Z., Fuks, Z, Kolesnick, R. (2024). Anti-Ceramide scFv prophylaxis for first responders to a limited nuclear attack Cell Physiol Biochem, 58:418-430.
  3. Nagesh, P. K. B., Monette, S., Shamu, T., Giralt, S., …, & Kolesnick, R. (2023). Anti-ceramide Single-Chain Variable Fragment Mitigates Gastrointestinal-Acute Radiation Syndrome and Improves Marrow Reconstitution, Rendering Near-Normal 90-Day Autopsies. Int J Radiat Oncol Biol Phys., S0360-3016(23)07728-3. Advance online publication.
  4. Rotolo, J. A., Fong, C. S., Bodo, S., … & Kolesnick, R. (2021).  Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair. JCI Insight, 6(8): e145380.
  5. Hammer, S. S., & Busik, J. V. (2017). The role of dyslipidemia in diabetic retinopathy. Vision res, 139:228–236.
  6. Hua, G., Wang, C., Pan, Y., … Paty, P. B., & Kolesnick, R. (2017). Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells. Cancer Res, 77(8):2124–2133.
  7. Kady, N., Yan, Y., Salazar, T., Wang, Q., Chakravarthy, … & Busik, J. (2017). Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes, J Clin Lipidol, 11(3):694-703.
  8. Chakravarthy, H., Navitskaya, S., O’Reilly, S., Gallimore, J., Mize, H., … & Busik, J. V.  (2016).  Role of acid sphingomyelinase in shifting the balance between proinflammatory and reparative bone marrow cells in diabetic retinopathy. Stem Cells, 34(4):972-83.
  9. Brenner, C., Galluzzi, L., Kepp, O., & Kroemer, G. (2013).  Decoding cell death signals in liver inflammation. J Hepatol, 59(3):583-94.
  10. Li, P.L. & Zhang, Y. (2013).  Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease. Handbook of experimental pharmacology, (216):171–197.
  11. Tikhonenko, M., Lydic, T. A., Opreanu, M., Li Calzi, S., Bozack, S., … & Busik, J. V. (2013). N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. PloS one, 8(1):e55177.
  12. Rotolo, J., Stancevic, B., … & Kolesnick, R.  (2012).  Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest., 122(5):1786-90.
  13. Hua, G., Thin, T. H., Feldman, R., Haimovitz-Friedman, A., … & Kolesnick, R. (2012). Crypt base columnar stem cells in small intestines of mice are radioresistant.  Gastroenterology, 143(5): 1266–1276.
  14. Opreanu, M., Tikhonenko, M., Bozack, S., … Kolesnick, R., Grant, M. B., & Busik, J. V. (2011).  The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes, 60(9):2370-2378.
  15. Boini, K. M., Zhang, C., Xia, M., Han, W. Q., Brimson, C., Poklis, J. L., et al. (2010). Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells. Biochimica et Biophysica Acta, 1801(12):1294–1304.
  16. Opreanu, M., Lydic, T. A., Reid, G. E., McSorley, K. M., Esselman, W. J., & Busik, J. V. (2010). Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid. Invest Ophthalmol Vis Sci, 51(6): 3253–3263.
  17. Stancevic, B., & Kolesnick R. (2010). Ceramide-rich platforms in transmembrane signaling, FEBS Lett, 584(9):1728–1740.
  18. Yi, F., Jin, S., Zhang, F., Xia, M., Bao, J. X., Hu, J., et al. (2009).  Formation of lipid raft redox signalling platforms in glomerular endothelial cells: an early event of homocysteine-induced glomerular injury. Journal of cellular and molecular medicine, 13(9B):3303–3314.
  19. Zhang Y., Li X., Becker K.A., Gulbins, E. (2009).  Ceramide-enriched membrane domains—Structure and function. BBA– Biomembranes, 1788(1):178-183.
  20. Medler, T.R., Petrusca, D.N., Lee, P.J., Hubbard, W.C., Berdyshev, E.V., Skirball, J., et.al. (2008).  Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. Am J Respiratory Cell and Mol Biol, 38(6):639–646.
  21. Osawa, Y., Uchinami, H., Bielawski, J., Schwabe, R.F., Hannun, Y.A., Brenner, D.A. (2005).  Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-a. J Biol Chem, 280(30):27879-27887.
  22. Rotolo, J. A., Zhang, J., Donepudi, M., Lee, H., Fuks, Z., & Kolesnick, R. (2005). Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem, 280(28):26425–26434.
  23. Göggel, R., Winoto-Morbach, S., Vielhaber, G., Imai, Y., Lindner, K., Brade, L., et.al. (2004).  PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nature medicine, 10(2):155–160.
  24. Grassmé, H., Cremesti, A., Kolesnick, R., & Gulbins, E. (2003). Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene, 22(35):5457–5470.
  25. Cremesti, A., Paris, F., Grassmé, … & Kolesnick, R. (2001). Ceramide enables fas to cap and kill. J Biol Chem, 276(26):23954–23961.
  26. Grassme, H., Jekle, A., Riehle, A., Schwarz, H., … Kolesnick, R., & Gulbins, E.  (2001). CD95 signaling via ceramide-rich membrane rafts. J Biol Chem, 276:20589–20596.
  27. Grassmé, H., Schwarz, H., & Gulbins, E. (2001).  Molecular mechanisms of ceramide-mediated CD95 clustering. Biochem Biophys Res Commun, 284(4):1016–1030.
  28. Paris, F., Fuks, Z., Kang, A., Capodieci, P., Juan, G., … & Kolesnick, R. (2001).  Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science, 293:293-297.
  29. Paris, F., Grassmé, H., Cremesti, A., … & Kolesnick, R. (2001). Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem, 276(11):8297–8305.
  30. Kirschnek, S., Paris, F., Weller, M., … Kolesnick, R., & Gulbins, E. (2000). CD95-mediated apoptosis in vivo involves acid sphingomyelinase. J Biol Chem, 275(35):27316–27323
  31. Verheij, M., Bose, R., Lin, X. H., Yao, B., …  Kolesnick, R. N. (1996). Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 380(6569):75–79.
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